Unimolecular micelles of amphiphilic cyclodextrin-core star-like block copolymers for anticancer drug delivery.
نویسندگان
چکیده
Well-defined star-like amphiphilic polymers composed of a β-cyclodextrin core, from which 21 hydrophobic poly(lactic acid) arms and hydrophilic poly(ethylene glycol) arms are grafted sequentially, form robust and uniform unimolecular micelles that are biocompatible and efficient in the delivery of anticancer drugs.
منابع مشابه
Systematic design and application of unimolecular star-like block copolymer micelles: a coarse-grained simulation study.
Unimolecular polymeric micelles have several features, such as thermodynamic stability, small particle size, biocompatibility, and the ability to internalize hydrophobic molecules. These micelles have recently attracted significant attention in various applications, such as nano-reactors, catalysis, and drug delivery. However, few attempts have explored the formation mechanisms and conditions o...
متن کاملNovel Amphiphilic Multi-Arm, Star-Like Block Copolymers as Unimolecular Micelles
Novel Amphiphilic Multi-Arm, Star-Like Block Copolymers as Unimolecular Micelles Xinchang Pang, Lei Zhao, Mufit Akinc, Jin Kon Kim, and Zhiqun Lin* Department of Materials Science and Engineering, Iowa State University, Ames, Iowa 50011, United States School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, United States Department of Chemical Engine...
متن کاملAmphiphilic star-block copolymers and supramolecular transformation of nanogel-like micelles to nanovesicles.
Amphiphilic star-block copolymers based on poly(3-hydroxybutyrate) with adamantyl end-functionalization were synthesized via anionic ring-opening polymerization and alkyne-azide "Click Chemistry" coupling. In aqueous medium, the copolymers self-assembled into nanogel-like large compound micelles, and transformed into vesicular nanostructures under the direction of host-guest interaction between...
متن کاملTheranostic Unimolecular Micelles Based on Brush-Shaped Amphiphilic Block Copolymers for Tumor-Targeted Drug Delivery and Positron Emission Tomography Imaging
Brush-shaped amphiphilic block copolymers were conjugated with a monoclonal antibody against CD105 (i.e., TRC105) and a macrocyclic chelator for (64)Cu-labeling to generate multifunctional theranostic unimolecular micelles. The backbone of the brush-shaped amphiphilic block copolymer was poly(2-hydroxyethyl methacrylate) (PHEMA) and the side chains were poly(L-lactide)-poly(ethylene glycol) (PL...
متن کاملAmphiphilic Block Copolymer Nano-micelles: Effect of Length Ratio of the Hydrophilic Block
Block copolymer nano-micelles are especially important in cancer treatment because of their fine dimensions. In this article, three systems of amphiphilic copolymers with similar lengths and different ratios of the hydrophobic and hydrophilic chains are studied using implicit-solvent coarse-grained molecular dynamics simulations. The factor fphil is defined as the ratio of the number...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Chemical communications
دوره 51 87 شماره
صفحات -
تاریخ انتشار 2015